Call for Abstract
21st International Meet on Medicinal Chemistry & Drug Design, will be organized around the theme “Innovative solutions to the greatest challenges and motivating in medicinal chemistry and drug discovery”
Medicinal Chemistry 2020 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Medicinal Chemistry 2020
Submit your abstract to any of the mentioned tracks.
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Medicinal chemistry-based plans are essentially aimed at the chemical modification of low molecular weight drugs in order to increase their lipophilicity or the intention of proper prodrugs, although this assessment will concentration mainly on the use of prodrugs and not analog development. Recently, interest has been concentrated on the design and evaluation of prodrugs that are capable of misusing one or more of the many endogenous transport systems at the level of the blood brain barrier (BBB). The scientific plans are mostly non-invasive approaches of drug transferal to malignancies of the central nervous system (CNS) and are founded on the use of nanosystems (colloidal carriers) such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles and dendrimers. The biodistribution of these nanocarriers can be manipulated by modifying their surface physico-chemical properties or by coating them with surfactants and polyethylene-glycols (PEGs). Liposomes, surfactant covered polymeric nanoparticles, and solid lipid nanoparticles are promising systems for transfer of drugs to tumors of the CNS. This mini journal discusses issues concerning the scope and limitations of both the medicinal chemistry and scientific approaches. Based on the current findings, it can be concluded that crossing of the BBB and drug transfer to CNS is very multifarious and requires a multidisciplinary approach such as a next to collaboration and collective efforts among researchers of several scientific areas, mainly medicinal chemists, biologists and pharmaceutical technicians.
- Track 1-1Target discovery and validation
- Track 1-2Molecular modelling
- Track 1-3Advances in medicinal chemistry
- Track 1-4Drug receptor interactions
- Track 1-5Toxicity, and therapeutic applications of antibiotics, antifungals, and antiviral
- Track 1-6 Chemotherapeutic Agents
- Structure-based drug design, virtual screening starts with processing the 3D target structural information of interest. The target structure may be derived from experimental data (X-ray, NMR or neutron scattering spectroscopy), homology modeling, or from Molecular Dynamics (MD) simulations. There are numerous fundamental issues that should be examined when considering a biological target for SBVS; for example, the druggability of the receptor, the choice of binding site, the selection of the most relevant protein structure, incorporating receptor flexibility, suitable assignment of protonation states, and consideration of water molecules in a binding site, to name a few. In fact, the identification of ligand binding sites on biological targets is becoming increasingly important. The need for novel modulators of protein/gene function has recently directed the scientific community to pursue druggable allosteric binding pockets. Another consideration for SBVS includes the careful choice of the compound library to be screened in the VS exercise according to the target in question, and the preprocessing of libraries in order to assign the proper stereochemistry, tautomeric, and protonation states.
- Track 2-1Protein biochemistry
- Track 2-2Organic synthesis of ligands and inhibitors
- Track 2-3Drug metabolism
- Track 2-4Molecular biology and genetic engineering
- Track 2-5Ligand and structure based drug design
Computer-Aided Drug Design is an important journal for all medicinal chemists who wish to be kept informed and up-to-date with all the latest and important developments in computer-aided methodologies and their applications in drug discovery. Each issue contains a series of timely, in-depth reviews mini-reviews, unique research articles and letter articles written by leaders in the field, covering a range of computational techniques for drug design, broadcast, ADME studies, theoretical chemistry; computational chemistry; computer and molecular graphics; molecular modeling; protein engineering; drug design; expert systems; general structure-property relationships; molecular dynamics; chemical database development and usage etc., providing excellent rationales for drug expansion.
- Track 3-1Computational Chemistry
- Track 3-2Enzyme as target
- Track 3-3Receptor as target
- Track 3-4QSAR/QSPR Quantitative structure activity/property relationships
Cancer is one of the major health hazards and the prominent cause of death in the world. A number of anticancer agents are currently in clinical practice and used for treatment of many kinds of cancers. There is no disbelief that the current resource of anticancer agents is insufficient due to the high occurrence of side effects and multidrug resistance. In the efforts to develop appropriate anticancer drugs, medicinal chemists have focused on coumarin derivatives. Coumarin is a certainly occurring compound and a versatile synthetic scaffold owning wide spectrum of biological effects including potential anticancer activity. This journal article covers the modern improvements of coumarin-based anticancer agents and also discusses the structure–activity relationship of the greatest potent compounds
- Track 4-1 Classification of Anti-Cancer Drugs
- Track 4-2 Chemotherapy
- Track 4-3 Anticancer and Anti-Diabetic Agents
- Track 4-4 Chemotherapeutic Agents
Bioorganic Chemistry goes explanations of research that are at the line of chemistry and biology. The controlling principle that the Editorial Board will follow in accepting manuscripts for publication is that the study either uses the principles and skills of organic and physical organic chemistry in struggling to solve some problem of relevance to biology or describes chemical studies that are inspired by some biological observation. Within this context, manuscripts suitable for plan are ones that deal with such matters as enzymology, enzyme models, biosynthesis and combinatorial biosynthesis, biomimetic synthesis, molecular recognition, protein and peptide chemistry, nucleic acid chemistry.
- Track 5-1 Bromodomain inhibitor
- Track 5-2 BET proteins
- Track 5-3 Apoptosis
- Track 5-4 Multi-target-directed ligands