Medicinal Chemistry and Drug Delivery

Medicinal chemistry-based plans are essentially aimed at the chemical modification of low molecular weight drugs in order to increase their lipophilicity or the intention of proper prodrugs, although this assessment will concentration mainly on the use of prodrugs and not analog development. Recently, interest has been concentrated on the design and evaluation of prodrugs that are capable of misusing one or more of the many endogenous transport systems at the level of the blood brain barrier (BBB). The scientific plans are mostly non-invasive approaches of drug transferal to malignancies of the central nervous system (CNS) and are founded on the use of nanosystems (colloidal carriers) such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles and dendrimers. The biodistribution of these nanocarriers can be manipulated by modifying their surface physico-chemical properties or by coating them with surfactants and polyethylene-glycols (PEGs). Liposomes, surfactant covered polymeric nanoparticles, and solid lipid nanoparticles are promising systems for transfer of drugs to tumors of the CNS. This mini journal discusses issues concerning the scope and limitations of both the medicinal chemistry and scientific approaches. Based on the current findings, it can be concluded that crossing of the BBB and drug transfer to CNS is very multifarious and requires a multidisciplinary approach such as a next to collaboration and collective efforts among researchers of several scientific areas, mainly medicinal chemists, biologists and pharmaceutical technicians.

  • Target discovery and validation
  • Molecular modelling
  • Advances in medicinal chemistry
  • Drug receptor interactions
  • Toxicity, and therapeutic applications of antibiotics, antifungals, and antiviral
  • Chemotherapeutic Agents

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